How Do You Spell BRADYKININASE?

Pronunciation: [bɹˈadɪkˌɪnɪnˌe͡ɪs] (IPA)

Bradykininase is spelled as /breɪdɪˈkɪnɪneɪs/, with emphasis on the second syllable. The first part, "bradykinin," refers to a type of peptide hormone, while the suffix "-ase" indicates an enzyme that breaks down or hydrolyzes something. Therefore, bradykininase is an enzyme that breaks down bradykinin, which helps regulate blood pressure and inflammation. The spelling of this word can be a bit tricky due to the combination of the long sound of "i," the short "e" sound, and the ending "-ine." Nonetheless, the IPA phonetic transcription effectively explains its pronunciation.

BRADYKININASE Meaning and Definition

1. Bradykininase is an enzyme that plays a crucial role in regulating the levels of bradykinin in the body. Bradykinin is a potent peptide that is involved in various physiological processes, including inflammation, pain perception, and blood pressure regulation. The enzyme bradykininase is responsible for breaking down bradykinin into inactive metabolites, thereby controlling its activity.

   Bradykininase is primarily found in the plasma and tissues throughout the body, including the lungs, kidneys, and blood vessels. It belongs to the class of metallopeptidases, as it contains a metal ion cofactor, typically zinc, that is essential for its enzymatic activity.

   The activity of bradykininase is tightly regulated to maintain the balance of bradykinin levels in the body. Dysregulation of this enzyme can lead to various pathological conditions. For instance, a deficiency or impairment in bradykininase activity can result in elevated levels of bradykinin, leading to excessive inflammation, pain, and vasodilation.

   Pharmaceutical research has focused on developing inhibitors of bradykininase as potential therapeutic agents for diseases associated with abnormal bradykinin levels, such as hereditary angioedema and acute respiratory distress syndrome. Additionally, understanding the precise mechanisms of bradykininase action and regulation can provide insights into the intricate pathways involved in bradykinin metabolism and its physiological functions.

Common Misspellings for BRADYKININASE

• vradykininase
• nradykininase
• hradykininase
• gradykininase
• beadykininase
• bdadykininase
• bfadykininase
• btadykininase
• b5adykininase
• b4adykininase
• brzdykininase
• brsdykininase
• brwdykininase
• brqdykininase
• brasykininase
• braxykininase
• bracykininase
• brafykininase
• brarykininase
• braeykininase

Etymology of BRADYKININASE

The word "Bradykininase" is derived from two parts: "Bradykinin" and "ase".

1. "Bradykinin": This term is derived from the words "brady-" meaning slow or sluggish, and "kinin" referring to a type of polypeptide hormone. Kinins play a role in various physiological processes including inflammation, pain sensation, and blood pressure regulation. Bradykinin, specifically, is a peptide that causes blood vessels to dilate, leading to increased blood flow and a decrease in blood pressure.

2. "-ase": The suffix "-ase" is commonly used in the naming of enzymes to signify that the word refers to an enzyme. Enzymes are proteins that act as biological catalysts and facilitate chemical reactions in living organisms.