Berger disease, also known as IgA nephropathy, is a chronic kidney disorder that affects the glomeruli, which are tiny filtering units in the kidneys responsible for removing waste products and excess fluid from the blood. It is named after Dr. Jean Berger, who first described this condition in 1968.
In Berger disease, abnormal deposits of immunoglobulin A (IgA) accumulate in the glomeruli, leading to inflammation and damage. IgA is an antibody that helps the body fight infections, but in this condition, it is mistakenly produced in excess and deposited in the kidneys, triggering an inflammatory response. Over time, this inflammation can impair the kidney's ability to filter waste products efficiently, resulting in the buildup of toxins and fluid in the body.
The exact cause of Berger disease is not fully understood, but it is believed to involve a combination of genetic and environmental factors. It often occurs after an upper respiratory or gastrointestinal infection, suggesting that certain infections may trigger or contribute to the development of this condition.
The most common symptom of Berger disease is blood in the urine (hematuria), which may be visible or detected through a microscopic examination. Other signs and symptoms may include proteinuria (excess protein in the urine), high blood pressure, swelling (edema) in the legs or around the eyes, and decreased kidney function.
Treatment for Berger disease focuses on managing symptoms, slowing down the progression of kidney damage, and reducing the risk of complications. This may involve medications to control blood pressure, reduce inflammation, and prevent infections. In some cases, more aggressive treatments, such as immunosuppressive drugs or corticosteroids, may be recommended to prevent further kidney damage. Regular monitoring and follow-up with a healthcare professional specializing in kidney disorders are crucial for
