Basic Fibroblast Growth Factor (bFGF) is a significant protein involved in cell division, tissue repair, and the promotion of angiogenesis. It is a member of the fibroblast growth factor (FGF) family, which includes several other important growth factors involved in various biological processes. bFGF is a single-stranded polypeptide chain consisting of approximately 155 amino acids.
bFGF plays a crucial role in embryonic development, wound healing, and maintaining tissue homeostasis in adult organisms. It stimulates the proliferation and migration of various cell types, including fibroblasts, endothelial cells, and smooth muscle cells, which contributes to tissue regeneration and repair. It also possesses potent angiogenic properties, promoting the formation of new blood vessels and enhancing blood flow to the affected area.
Additionally, bFGF has been implicated in various physiological and pathological conditions, including cancer. It has been shown to act as a mitogen, inducing cell growth and proliferation in various tumor types. Furthermore, it is involved in tumor neovascularization, helping to create a blood supply for tumor growth.
Research into the therapeutic applications of bFGF has shown promising potential for the treatment of various conditions, including cardiovascular diseases, neurodegenerative disorders, and chronic wounds. Clinical trials have investigated its use in promoting tissue regeneration and repairing damaged organs.
Overall, bFGF is a critical growth factor that exerts profound effects on cell proliferation, tissue repair, and angiogenesis, making it a crucial molecule in normal development, tissue maintenance, and pathological processes.
