BAND III PROTEIN Meaning and
Definition
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Band III protein, also known as anion exchanger protein, is a crucial integral membrane protein that is found in erythrocytes (red blood cells). It plays a significant role in the transport of chloride ions across the erythrocyte membrane, contributing to the maintenance of the appropriate ionic balance required for cellular homeostasis.
The band III protein is responsible for the exchange of chloride ions (Cl-) and bicarbonate ions (HCO3-) across the erythrocyte membrane, facilitating the removal of carbon dioxide (CO2) from the bloodstream. This process is essential for efficient respiration by enabling the transportation of CO2 from the tissues to the lungs for elimination.
The band III protein consists of 911 amino acids, and it is encoded by the SLC4A1 gene located on chromosome 17 in humans. It features two large cytoplasmic domains on either side of the erythrocyte membrane, along with 12 membrane-spanning segments that serve as channels for transporting ions. Several isoforms of the band III protein exist, each with slightly different characteristics and tissue distribution.
Defects or mutations in the band III protein can lead to various disorders, such as hereditary spherocytosis, hereditary elliptocytosis, or Southeast Asian ovalocytosis, which are characterized by abnormal red blood cell shape and impaired membrane function. Understanding the structure and function of band III protein is essential for elucidating the underlying mechanisms and potential therapeutic interventions for these disorders.
Common Misspellings for BAND III PROTEIN
- vand iii protein
- nand iii protein
- hand iii protein
- gand iii protein
- bznd iii protein
- bsnd iii protein
- bwnd iii protein
- bqnd iii protein
- babd iii protein
- bamd iii protein
- bajd iii protein
- bahd iii protein
- bans iii protein
- banx iii protein
- banc iii protein
- banf iii protein
- banr iii protein
- bane iii protein
- band uii protein
- band jii protein
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