AZACYTIDINE Meaning and
Definition
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Azacytidine is a chemical compound that belongs to the class of nucleoside analogs. It is a cytidine analogue in which the nitrogen atom in the six-membered pyrimidine ring is replaced by a carbon atom. This modification results in the formation of a heterocyclic ring known as an azacycle. Azacytidine has gained significant attention as a cytotoxic and demethylating agent in cancer research and therapy.
Azacytidine exhibits anticancer properties by inhibiting DNA and RNA synthesis. It functions by incorporating into the DNA molecule during replication, leading to the formation of covalent bonds between azacytidine and DNA. This incorporation disrupts the normal DNA structure and obstructs the activity of DNA methyltransferases, enzymes responsible for DNA methylation. By inhibiting DNA methylation, azacytidine contributes to the re-expression of silenced genes and promotes differentiation and apoptosis in cancer cells.
Azacytidine is primarily used in the treatment of myelodysplastic syndromes (MDS), a group of disorders in which the bone marrow fails to produce enough healthy blood cells. It has also shown promising results in the treatment of acute myeloid leukemia (AML) and other hematological malignancies. Additionally, research is being conducted to explore its potential in the treatment of solid tumors.
Despite its therapeutic potential, azacytidine may have side effects such as bone marrow suppression, gastrointestinal disturbances, and liver toxicity. Dosage and administration of azacytidine require close monitoring and adherence to medical guidelines.
Common Misspellings for AZACYTIDINE
- zzacytidine
- szacytidine
- wzacytidine
- qzacytidine
- axacytidine
- aaacytidine
- azzcytidine
- azscytidine
- azwcytidine
- azqcytidine
- azaxytidine
- azavytidine
- azafytidine
- azadytidine
- azacttidine
- azacgtidine
- azac7tidine
- azac6tidine
- azacyridine
- azacyfidine
Etymology of AZACYTIDINE
The word "Azacytidine" is composed of two main components: "aza" and "cytidine".
The prefix "aza-" is derived from the Greek word "ἀζα" (aza), which means "replacing" or "substituting". In chemistry, the prefix "aza-" is used to indicate the substitution of carbon in a heterocyclic compound with nitrogen.
"Cytidine" is derived from "cytidine", which is a nucleoside composed of the nucleobase cytosine and the sugar ribose. The suffix "-idine" indicates that it is a nucleoside.
Therefore, "Azacytidine" can be interpreted to mean a compound where the carbon in the cytidine molecule is substituted by nitrogen.
Similar spelling word for AZACYTIDINE
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