How Do You Spell ASPARTOKINASE HOMOSERINE DEHYDROGENASE?

Pronunciation: [ɐspˈɑːtəkˌɪne͡ɪs hˌə͡ʊmə͡ʊsəɹˈiːn dˌiːha͡ɪdɹˈə͡ʊd͡ʒne͡ɪs] (IPA)

The term "Aspartokinase Homoserine Dehydrogenase" is a mouthful to pronounce and spell, but it represents two important enzymes in the biosynthesis of amino acids. The term can be broken down into four syllables: "as-par-to-ki-nase" and "ho-mo-se-rine de-hy-dro-gen-ase." Using IPA phonetic transcription, aspar-to-ki-nase can be written as /æˈspɑrtəʊkaɪneɪs/ and ho-mo-se-rine de-hy-dro-gen-ase as /ˌhɒməʊsəˈriːn diːhaɪdrədʒɪneɪs/. Despite its complexity, this term is essential for researchers studying the biosynthesis of amino acids.

ASPARTOKINASE HOMOSERINE DEHYDROGENASE Meaning and Definition

1. Aspartokinase Homoserine Dehydrogenase (AK-HSD) is an enzyme that plays a crucial role in the biosynthesis of the essential amino acids threonine and lysine in microorganisms. It is a bifunctional enzyme that consists of two distinct catalytic activities – aspartokinase (AK) and homoserine dehydrogenase (HSD).

   The aspartokinase function of this enzyme catalyzes the phosphorylation of aspartate, an amino acid derived from the central metabolic pathway, to form β-aspartyl phosphate. This phosphorylation reaction occurs through the transfer of the terminal phosphate group of ATP to aspartate, resulting in the production of ADP. This first step is often the rate-limiting step in the biosynthesis of threonine and lysine.

   The second catalytic activity, homoserine dehydrogenase, is responsible for the conversion of L-homoserine to L-aspartate semialdehyde. This step involves the oxidation of homoserine by the transfer of a hydride ion to an NAD+ cofactor, producing NADH and releasing ammonia as a byproduct.

   The entire AK-HSD enzyme complex plays a crucial role in regulating the flux of metabolites in the pathway leading to threonine and lysine synthesis. Through the coordinated action of both aspartokinase and homoserine dehydrogenase activities, this enzyme allows for the production of the essential amino acids required for protein synthesis and other cellular processes in microorganisms. Understanding the structure and function of this enzyme is of significant importance for studying and manipulating metabolic pathways in organisms, including bacterial strains used in biotechnology and metabolic engineering applications.

Common Misspellings for ASPARTOKINASE HOMOSERINE DEHYDROGENASE

• zspartokinase homoserine dehydrogenase
• sspartokinase homoserine dehydrogenase
• wspartokinase homoserine dehydrogenase
• qspartokinase homoserine dehydrogenase
• aapartokinase homoserine dehydrogenase
• azpartokinase homoserine dehydrogenase
• axpartokinase homoserine dehydrogenase
• adpartokinase homoserine dehydrogenase
• aepartokinase homoserine dehydrogenase
• awpartokinase homoserine dehydrogenase
• asoartokinase homoserine dehydrogenase
• aslartokinase homoserine dehydrogenase
• as-artokinase homoserine dehydrogenase
• as0artokinase homoserine dehydrogenase
• aspzrtokinase homoserine dehydrogenase
• aspsrtokinase homoserine dehydrogenase
• aspwrtokinase homoserine dehydrogenase
• aspqrtokinase homoserine dehydrogenase
• aspaetokinase homoserine dehydrogenase
• aspadtokinase homoserine dehydrogenase