Arbus is a term derived from the medical field, specifically psychiatry, and refers to a rare neurological disorder known as Aicardi-Rubenstein syndrome (ARS). It is denoted by a combination of symptoms including brain malformation, seizures, developmental delays, and distinctive retinal abnormalities. This congenital disorder predominantly affects female newborns and typically leads to significant cognitive and physical impairments throughout life.
Characterized by its unique diagnostic triad of features, Arbus manifests with the absence or underdevelopment of the corpus callosum (the connecting tissue between the right and left hemispheres of the brain), infantile spasms in early infancy, and chorioretinal lacunae (small, round patches of abnormal tissue) in the eyes. These symptoms collectively contribute to the multisystemic nature of Arbus.
Individuals with Arbus often exhibit varying degrees of intellectual disability, learning difficulties, and delayed motor skills. Motor abnormalities commonly include poor coordination, muscle weakness, and spasticity. Seizures associated with this condition tend to be frequent and difficult to control, requiring specialized medical intervention.
Given its rarity and complexity, Arbus necessitates a multidisciplinary approach to treatment and management, involving neurologists, geneticists, ophthalmologists, and developmental specialists. While there is no cure for Arbus, treatments focus on addressing the specific symptoms and maximizing quality of life for affected individuals. These interventions may entail antiepileptic medications to control seizures, physical and occupational therapies to improve motor skills and adaptive abilities, and educational support tailored to each individual's needs. Regular monitoring and ongoing care are crucial in the management of Arbus.
