How Do You Spell APRTASE?

Pronunciation: [ˈapɹə tˈe͡ɪz] (IPA)

APRTase, pronounced as /ˈæpərtˌeɪz/, is an acronym for Adenine Phosphoribosyl Transferase. The phonetic transcription of the word APRTase helps clarify the pronunciation of each syllable, starting with the primary stress on the "eɪ" vowel sound. Additionally, the transcription indicates that the P and the R are pronounced distinctly using aspiration and retroflexion respectively. Adenine Phosphoribosyl Transferase is an enzyme, which plays a crucial role in purine metabolism. It is important to spell this word correctly to ensure clear communication in the field of biochemistry.

APRTASE Meaning and Definition

1. APRTase stands for Adenine Phosphoribosyltransferase, which is an enzyme responsible for the catalysis of the transfer of phosphoribosyl moiety from phosphoribosyl pyrophosphate (PRPP) molecule to adenine, resulting in the formation of adenine mononucleotide (AMP) and pyrophosphate. This enzyme plays a crucial role in both purine salvage pathway and nucleotide metabolism.

   In the context of purine salvage pathway, APRTase assists in recycling adenine, a purine base, by converting it into AMP. This process is particularly important in cells lacking de novo purine synthesis pathway or cells with high energy demand, as it allows the cell to readily replenish its adenine pool and maintain efficient nucleotide metabolism. Moreover, the activity of APRTase also prevents the accumulation of excess adenine, which can be toxic to cells.

   Biochemically, APRTase is categorized as a transferase enzyme, as it facilitates the transfer of a functional group (phosphoribosyl moiety) from one molecule to another. The enzyme requires the presence of PRPP and adenine as substrates to catalyze the reaction. APRTase functions optimally at physiological pH and temperature, utilizing a divalent cation, such as magnesium (Mg2+), as a cofactor.

   In summary, APRTase is an essential enzyme involved in the purine salvage pathway and nucleotide metabolism. Its role is to transfer a phosphoribosyl moiety from PRPP to adenine, generating AMP and pyrophosphate. This enzyme aids in maintaining cellular purine homeostasis and serves as a crucial player in nucleotide biosynthesis.

Common Misspellings for APRTASE

• APRTise
• APRTese
• APRTcse
• APRTa3e
• APRTace
• APRTaqe
• APRTare
• APRTasu
• APRTasm
• APRTasa
• APRTasg
• apr tase
• aprt ase
• aprta se
• aprtas e

Etymology of APRTASE

The word "APRTase" is derived from the acronym APRT, which stands for Adenine Phosphoribosyltransferase. The suffix "-ase" is commonly used in biochemistry to indicate an enzyme. APRTase refers to the enzyme that catalyzes the transfer of a phosphoribosyl group from phosphoribosyl pyrophosphate (PRPP) onto adenine, converting it into adenine monophosphate (AMP).