APOLIPOPROTEIN A Meaning and
Definition
-
Apolipoprotein A (ApoA) is a class of proteins that plays a crucial role in the metabolism and transportation of lipids, predominantly cholesterol and triglycerides, in the body. It is a key component of high-density lipoprotein (HDL), often referred to as the "good cholesterol."
Apolipoprotein A is encoded by the APOA1 gene and primarily synthesized in the liver. It exists in two major isoforms, ApoA-I and ApoA-II, each performing distinct functions. ApoA-I is the major protein constituent of HDL and is responsible for its structure and function. It serves as a cofactor for the enzyme lecithin-cholesterol acyltransferase (LCAT), which converts free cholesterol into cholesterol esters, an essential step for lipid transport.
Moreover, ApoA-I influences the reverse cholesterol transport pathway, orchestrating the removal of excess cholesterol from peripheral cells and tissues and its transport back to the liver for elimination. This mechanism helps to prevent cholesterol build-up in blood vessels, reducing the risk of atherosclerosis and cardiovascular diseases.
ApoA-II, although less abundant than ApoA-I, is also associated with HDL particles. It is involved in the regulation of lipid metabolism, bile acid synthesis, and inflammation.
Mutations or deficiencies in ApoA can lead to various disorders, including familial hypoalphalipoproteinemia, a condition characterized by abnormally low levels of HDL cholesterol. This can increase the risk of developing cardiovascular diseases.
In summary, Apolipoprotein A is a group of proteins that play a critical role in lipid metabolism and transportation, with ApoA-I being the major constituent of HDL particles. Their functions include facilitating reverse cholesterol transport, preventing
Common Misspellings for APOLIPOPROTEIN A
- zpolipoprotein a
- spolipoprotein a
- wpolipoprotein a
- qpolipoprotein a
- aoolipoprotein a
- alolipoprotein a
- a-olipoprotein a
- a0olipoprotein a
- apilipoprotein a
- apklipoprotein a
- apllipoprotein a
- applipoprotein a
- ap0lipoprotein a
- ap9lipoprotein a
- apokipoprotein a
- apopipoprotein a
- apooipoprotein a
- apolupoprotein a
- apoljpoprotein a
- apolkpoprotein a
Etymology of APOLIPOPROTEIN A
The word "Apolipoprotein A" originates from the combination of several terms:
1. "Apo-" is a prefix derived from the Greek word "apo" meaning "away from" or "separate". In biochemistry, "apo-" is often used to indicate a protein that has lost its binding partner or coenzyme.
2. "Lipoprotein" is a compound word consisting of "lipid" and "protein". "Lipid" refers to a class of molecules that includes fats, oils, and related substances, while "protein" refers to a large biomolecule composed of amino acids that is essential for many biological functions. Lipoproteins are complex molecules that transport lipids through the bloodstream.
3. "A" is a suffix that is often used in biochemistry to designate different subtypes or isoforms of a protein. It is derived from the first letter of the alphabet.
Infographic
Add the infographic to your website:
