APOA II Meaning and
Definition
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ApoA II, short for Apolipoprotein A-II, is a protein component found in lipoproteins. It is encoded by the APOA2 gene and is primarily synthesized in the liver, although it is also produced in the intestine and a few other tissues. ApoA II is a type of apolipoprotein—an essential protein that plays a crucial role in lipid metabolism and transport.
ApoA II is predominantly associated with high-density lipoproteins (HDL) in the plasma. It functions as an activator of the enzyme lecithin cholesterol acyltransferase (LCAT), which is involved in the transformation of cholesterol into cholesteryl esters. This conversion contributes to the formation of mature HDL particles and facilitates the reverse cholesterol transport pathway, where excess cholesterol is transported from peripheral tissues back to the liver for excretion.
The level of ApoA II in the blood is influenced by various factors like genetics, diet, hormonal factors, and lifestyle. Certain genetic variants in the APOA2 gene may impact the expression or structure of ApoA II, potentially affecting lipid metabolism and the risk of cardiovascular diseases. Studies have suggested associations between certain genetic variations in ApoA II and dyslipidemia, obesity, and metabolic syndrome.
Understanding the function and regulation of ApoA II is important in exploring its roles in health and disease. Research efforts are ongoing to elucidate its precise mechanisms and to develop potential strategies for therapeutic interventions targeting lipid-related disorders.
Common Misspellings for APOA II
- AqoA II
- ApgA II
- ApmA II
- ApnA II
- Apoi II
- Apoe II
- Apoc II
- ApoA0II
- ApoA yI
- ApoA aI
- ApoA mI
- ApoA hI
- ApoA Iy
- ApoA Ia
- ApoA Ih
- apo a ii
- apoa i i
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