Antithrombin III Human Plasma is a term that refers to a naturally occurring protein found in human blood plasma. It functions as a critical anticoagulant, meaning it plays a vital role in preventing excessive blood clotting within the body.
This protein, commonly abbreviated as AT-III or AT-3, is produced primarily in the liver and acts as an inhibitor of multiple coagulation factors. It works by binding to and inhibiting a key clotting protein called thrombin, as well as other clotting factors like IXa, Xa, XIa, and XIIa. By inhibiting these clotting factors, Antithrombin III effectively hinders the formation of blood clots and reduces the risk of thrombosis, which is the formation of blood clots within blood vessels.
Antithrombin III Human Plasma is used in clinical settings as a therapeutic agent, particularly in patients with congenital or acquired deficiencies of this protein. Administration of this plasma-derived product helps to restore the anticoagulant activity in individuals with low levels of endogenous antithrombin III.
Furthermore, Antithrombin III Human Plasma may be used as a prophylactic treatment to prevent blood clot formation during surgical procedures or in high-risk situations, such as patients with hereditary antithrombin III deficiency or those undergoing extracorporeal circulation.
Overall, Antithrombin III Human Plasma is a critical component of the body's natural anticoagulant system and a valuable therapeutic option in the management of clotting disorders.
