How Do You Spell ANTIGEN PRESENTATION?

Pronunciation: [ˈantɪd͡ʒˌɛn pɹˌɛzəntˈe͡ɪʃən] (IPA)

Antigen Presentation is the process by which immune cells present pieces of foreign substances called antigens to other cells of the immune system. The spelling of this word is /æn.tə.dʒən ˌprɛz.ənˈteɪ.ʃən/, with the stress on the third syllable "prez". The first syllable "ant" is pronounced with the short "a" sound, followed by the "t" consonant. The second syllable "i" is pronounced with the short "i" sound, followed by the "g" consonant. The final syllables "prez-ən-tay-shən" are pronounced with the stress on the third syllable and the standard American English pronunciation of the vowels.

ANTIGEN PRESENTATION Meaning and Definition

1. Antigen presentation refers to the vital immune process in which antigen-presenting cells (APCs) display fragments of antigens to other immune cells, such as T lymphocytes, in order to activate or regulate an immune response. Antigens are foreign substances, such as pathogens or harmful molecules, that trigger an immune response in the body.

   During antigen presentation, APCs, commonly dendritic cells, macrophages, or B cells, capture antigens and process them into smaller peptide fragments. These fragments are then presented on the APCs' cell surface using a class of proteins called major histocompatibility complex molecules (MHC). MHC class II molecules are involved in presenting antigens derived from extracellular pathogens, while MHC class I molecules present antigens from intracellular pathogens, as well as normal cellular proteins.

   Once the antigen fragments are displayed on the APCs, they interact with specific receptor molecules called T cell receptors (TCRs) present on the surface of T lymphocytes. This interaction serves as a recognition system for the immune system to distinguish between self and non-self antigens, enabling the immune system to mount an appropriate immune response.

   Antigen presentation is crucial for the initiation, coordination, and regulation of the immune response. By presenting antigens to T lymphocytes, antigen-presenting cells play a critical role in activating and directing immune cells to combat infections, mount adaptive immune responses, and eliminate abnormal cells, such as cancer cells. Additionally, antigen presentation also helps regulate immune responses, preventing excessive activation or inappropriate targeting of normal cells, known as autoimmunity.

Common Misspellings for ANTIGEN PRESENTATION

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Etymology of ANTIGEN PRESENTATION

The etymology of the word "antigen presentation" can be broken down as follows:

1. Antigen: The term "antigen" originates from two Greek words: "anti" meaning "against" and "gen" meaning "to produce" or "to give birth to". It was first coined in 1908 by the German immunologist Paul Ehrlich. Ehrlich used the term to describe substances that induce an immune response in the body.

2. Presentation: The word "presentation" derives from the Latin word "praesentare", which means "to exhibit" or "to show". It entered the English language in the early 15th century and has been used to describe the act of presenting something to an audience or making something known.

When combined, "antigen presentation" refers to the process in which an antigen is exhibited or shown to the immune system, triggering an immune response.

Plural form of ANTIGEN PRESENTATION is ANTIGEN PRESENTATIONS