How Do You Spell ANTIBODY DEPENDENT CELL CYTOXICITY?

Pronunciation: [ˈantɪbˌɒdi dɪpˈɛndənt sˈɛl sˌa͡ɪtəksˈɪsɪti] (IPA)

Antibody Dependent Cell Cytoxicity is a term used to describe the process by which antibodies bind to a specific target cell, leading to the destruction of that cell by other immune cells. The spelling of this term can be explained using the International Phonetic Alphabet (IPA) as follows: [ˈæntɪbɒdi dɪˈpɛndənt sɛl saɪtəˈtɒksɪsɪti]. This term is important in understanding how the immune system works to target and eliminate harmful cells in the body. Proper spelling and pronunciation of medical terms is vital in achieving accurate communication in healthcare settings.

ANTIBODY DEPENDENT CELL CYTOXICITY Meaning and Definition

1. Antibody Dependent Cell Cytotoxicity (ADCC) is a type of immune response that involves the destruction of target cells by the immune system. ADCC is mediated by a group of white blood cells known as natural killer (NK) cells, which possess the ability to recognize and eliminate cells tagged with specific antibodies.

   The process of ADCC begins when the immune system detects a foreign antigen on the surface of a target cell. This triggers the production of specific antibodies, which bind to the antigen and subsequently mark the cell for destruction. NK cells possess Fc receptors that are capable of binding to the constant region of these antibodies.

   Once the NK cell binds to the antibody-tagged target cell, it releases cytotoxic granules containing potent chemicals, such as perforin and granzymes, which puncture the target cell's membrane and initiate its destruction. This response can result in the death of infected cells, cancer cells, or other abnormal cells that express foreign or altered antigens.

   ADCC plays a crucial role in the immune defense against pathogens, particularly in combating viral infections. It also serves as an important mechanism for targeting and eliminating cancer cells, thereby contributing to the body's natural defense against tumors.

   The study of ADCC holds significant potential for the development of therapeutic interventions and vaccines, as it offers insights into enhancing immune responses and designing targeted therapies to harness the power of this immune mechanism for the treatment of various diseases.

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