How Do You Spell ANGIOTENSINOGENASE?

Pronunciation: [ˈaŋɡɪˌə͡ʊtənsˌɪnə͡ʊd͡ʒnˌe͡ɪs] (IPA)

Angiotensinogenase is a term that refers to a group of enzymes that play a vital role in the regulation of blood pressure. The word is pronounced as /æn.dʒioʊ.tɛn.sɪ.nəʊ.ɡə.neɪz/. It is a compound word that combines the words Angiotensinogen and -ase, which is a suffix indicating an enzyme. Angiotensinogen is a plasma protein that is converted into angiotensin, a potent vasoconstrictor, by the action of the enzyme renin. Thus, angiotensinogenase is involved in the regulation of blood pressure by controlling the level of angiotensin in the body.

ANGIOTENSINOGENASE Meaning and Definition

1. Angiotensinogenase is an enzyme that plays a crucial role in the regulation of blood pressure and fluid balance in the body. It is an endopeptidase, meaning that it catalyzes the hydrolysis or cleavage of specific peptide bonds within angiotensinogen, a precursor protein produced by the liver. This cleavage leads to the formation of angiotensin I, the inactive form of angiotensin.

   Angiotensinogenase is primarily produced and secreted by cells in the kidneys, but it can also be found in other tissues, including the liver, heart, and blood vessels. It acts on angiotensinogen, which is released into the bloodstream by the liver, and converts it into angiotensin I by cutting the peptide bond between amino acids Asp and Arg. Angiotensin I is then further converted to angiotensin II, an active hormone that acts on blood vessels to promote vasoconstriction and stimulate the release of aldosterone, a hormone that regulates sodium and water balance.

   By regulating the production of angiotensin II through the cleavage of angiotensinogen, angiotensinogenase plays a vital role in maintaining normal blood pressure levels and fluid balance in the body. Dysfunction or imbalance in angiotensinogenase activity can contribute to various health conditions, including hypertension (high blood pressure) and fluid retention. Therefore, angiotensinogenase is an important target for medical interventions aimed at controlling blood pressure and fluid homeostasis.

Common Misspellings for ANGIOTENSINOGENASE

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• anviotensinogenase
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