Angelicin is a naturally occurring compound found in a variety of plant sources, particularly in the Apiaceae family. It is a furanocoumarin derivative that possesses various biological and pharmacological properties. Angelicin is commonly extracted from plants such as angelica and celery, and it is also present in some botanical oils.
Chemically, angelicin belongs to the group of linear furanocoumarins and contains a furan ring fused with a coumarin moiety. It exhibits profuse absorption of ultraviolet light, making it phototoxic and capable of inducing photobiological effects on human skin. This compound has gained significant attention in both medicinal and cosmetic fields due to its photoactive properties.
In terms of pharmacology, angelicin has been found to possess antibacterial, antifungal, and anti-inflammatory activities. It has shown potential as an effective antimicrobial agent against various pathogens, particularly those associated with skin infections. Moreover, angelicin has demonstrated anti-inflammatory effects by inhibiting the production and release of pro-inflammatory mediators.
Additionally, angelicin has been investigated for its potential role in photodynamic therapy in the treatment of certain cancers. By combining angelicin with light, it is believed to generate reactive oxygen species, leading to the destruction of cancerous cells.
Overall, angelicin is a natural compound with diverse biological properties, including antimicrobial, anti-inflammatory, and potential anticancer activities. Its unique phototoxic behavior makes it a subject of interest in various fields, particularly in dermatology and cancer research.
