ANCITABINE Meaning and
Definition
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Ancitabine, also known as 1-(β-D-Arabinofuranosyl) cytosine or 1-β-D-arabinofuranosylcytosine, is a synthetic nucleoside analog and an antineoplastic agent used in chemotherapy. It is classified as a pyrimidine analog and functions by interfering with the replication process of cancer cells, ultimately inhibiting their growth and proliferation.
Ancitabine is structurally similar to the naturally occurring nucleoside cytidine, with a sugar molecule (β-D-Arabinofuranosyl) attached to the nucleobase cytosine. Once inside the cancer cell, this analog is phosphorylated by cellular enzymes, converting it into active triphosphate form known as ara-CTP. Ara-CTP acts as a competitive inhibitor of endogenous cytidine triphosphate, leading to premature termination of DNA synthesis during the S-phase of the cell cycle. This disruption in DNA replication prevents cancer cells from proliferating, eventually resulting in their death.
Due to its mechanism of action and its ability to inhibit DNA synthesis, ancitabine is particularly effective against rapidly dividing cells, such as those present in various forms of cancer. It has been used in the treatment of hematologic malignancies, including acute myeloid leukemia and myelodysplastic syndromes. Ancitabine may be administered intravenously or intrathecally, depending on the specific cancer being targeted.
While ancitabine has demonstrated efficacy in certain types of cancer, it may also have potential side effects, including bone marrow suppression, gastrointestinal disturbances, and liver toxicity. Therefore, its use must be closely monitored by healthcare professionals.
Common Misspellings for ANCITABINE
- zncitabine
- sncitabine
- wncitabine
- qncitabine
- abcitabine
- amcitabine
- ajcitabine
- ahcitabine
- anxitabine
- anvitabine
- anfitabine
- anditabine
- ancutabine
- ancjtabine
- ancktabine
- ancotabine
- anc9tabine
- anc8tabine
- ancirabine
- ancifabine
Etymology of ANCITABINE
The term "Ancitabine" is a compound word derived from two components: "anci-" and "-tabine".
The prefix "anci-" is related to the term "anti-", meaning “against” or “opposed to.” It is commonly used as a prefix in chemistry to denote a compound that has similar properties to another compound or inhibits a particular cellular process.
The second part, "-tabine", is derived from "nucleoside", a type of organic molecule composed of a nucleobase (the building blocks of DNA and RNA) attached to a sugar molecule.
When combined, "Ancitabine" refers to a particular compound that belongs to the nucleoside analog family and has therapeutic properties against certain diseases.
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