Amino Acid Transporter ASC is a transmembrane protein that facilitates the transport of amino acids across the cell membrane in a sodium-dependent manner. It belongs to the solute carrier family 1, which is involved in the uptake of various nutrients and metabolites.
ASC stands for "alanine-serine-cysteine" transporter, as it has a high affinity for these three amino acids. It is also known as the SLC1A5 transporter or the System ASC transporter.
Amino Acid Transporter ASC is primarily expressed in the kidneys, intestines, placenta, and the central nervous system. It plays a crucial role in nutrient absorption, particularly in the intestines, where it promotes the uptake of amino acids from the intestinal lumen into the bloodstream. In the kidneys, it is involved in the reabsorption of filtered amino acids to maintain their optimal levels in the body.
Furthermore, Amino Acid Transporter ASC has been implicated in various physiological and pathological processes. It is essential for protein synthesis, cell growth, and metabolism. Additionally, it has been associated with certain diseases, including cancer, where it promotes the supply of amino acids for tumor growth and proliferation.
In summary, Amino Acid Transporter ASC is a transmembrane protein involved in the transport of amino acids across the cell membrane. It has high affinity for alanine, serine, and cysteine, and is expressed in various tissues. It is crucial for nutrient absorption and metabolism, and its dysregulation can contribute to disease development.
