AMATOXINS Meaning and
Definition
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Amatoxins are a group of potent toxic substances that belong to the cyclopeptide alkaloid family. These compounds are primarily produced by a few species of poisonous mushrooms, such as the death cap mushroom (Amanita phalloides) and the destroying angel mushroom (Amanita bisporigera). The chemical structure of amatoxins consists of a cyclopeptide ring, including several amino acids.
Amatoxins are extremely poisonous and can cause severe damage to various organs. When ingested, they are resistant to heat, acidity, and enzymes in the gastrointestinal tract, allowing them to be easily absorbed by the body. Upon absorption, amatoxins target the liver cells, where they interfere with the synthesis of RNA polymerase II enzyme. This interruption eventually leads to the inhibition of protein synthesis, causing liver necrosis and failure.
Symptoms of amatoxin poisoning generally appear 6 to 24 hours after ingestion and may include severe abdominal pain, vomiting, diarrhea, and dehydration. As the toxins progress within the body, liver and kidney failure, encephalopathy, and death may occur if left untreated.
It is crucial to seek immediate medical attention should someone experience symptoms of amatoxin poisoning. Treatment typically involves removal of remaining mushrooms from the stomach and administration of activated charcoal, which binds to the toxins, reducing their absorption. Other measures may include supportive care, such as intravenous fluids and medications to manage symptoms. In severe cases, liver transplantation might be necessary for survival.
Etymology of AMATOXINS
The word "amatoxins" is derived from the Latin word "amānīta", which means "mushroom" or "toadstool". The suffix "-toxin" indicates that amatoxins are toxic substances found in certain types of mushrooms, particularly those of the Amanita genus. Amatoxins are known for their potent toxicity and are responsible for most of the deadly effects associated with mushroom poisoning.
