ALPHA CHIMAERIN Meaning and
Definition
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Alpha Chimaerin, also known as α-Chimaerin or α-CHN, is a protein enzyme that is encoded by the CHN1 gene in humans. It belongs to the RhoGAP (Rho GTPase-Activating Protein) family, specifically the chimerin subfamily. The chimerin proteins have a unique domain structure consisting of an N-terminal SH2 domain, a Rac-GAP (GTPase-activating protein) domain, and a pleckstrin homology (PH) domain.
Alpha Chimaerin plays a crucial role in regulating cellular processes such as cytoskeletal dynamics, membrane trafficking, and signal transduction pathways. Its main function is to act as a negative regulator of the Rho family of small G proteins, including Rac1 and Rac2. It achieves this by catalyzing the hydrolysis of GTP bound to these GTPases, thereby inactivating them.
This protein is involved in controlling processes such as cell adhesion, cell migration, and neuronal development, as well as modulating synaptic plasticity and neurotransmission in the brain. Its activity has likewise been associated with pathophysiological conditions, including cancer, neurodegenerative diseases, and cardiovascular disorders.
Studies have revealed that mutations in the CHN1 gene can lead to abnormal regulation of Rho GTPases and subsequent dysregulation of cellular processes, resulting in various diseases and disorders. Understanding the mechanisms and functions of alpha Chimaerin is crucial for unraveling its role in normal and pathological cellular processes, which may ultimately contribute to the development of therapeutic strategies for associated disorders.
Common Misspellings for ALPHA CHIMAERIN
- zlpha chimaerin
- slpha chimaerin
- wlpha chimaerin
- qlpha chimaerin
- akpha chimaerin
- appha chimaerin
- aopha chimaerin
- aloha chimaerin
- allha chimaerin
- al-ha chimaerin
- al0ha chimaerin
- alpga chimaerin
- alpba chimaerin
- alpna chimaerin
- alpja chimaerin
- alpua chimaerin
- alpya chimaerin
- alphz chimaerin
- alphs chimaerin
- alphw chimaerin
Etymology of ALPHA CHIMAERIN
The term "alpha Chimaerin" is derived from the combination of two components: "alpha" and "Chimaerin".
1. "Alpha": The word "alpha" originates from the Greek alphabet and is the first letter of that alphabet. In scientific and technical terminology, "alpha" often refers to a primary, dominant, or initial form. It can also be utilized to represent a particular subunit or variant within a larger group or system.
2. "Chimaerin": The term "Chimaerin" applies to a group of proteins known as GTPase-activating proteins (GAPs) that play a role in intracellular signaling processes. The name "Chimaerin" was given due to the protein's structural resemblance to a mythical creature called "chimaera" or "chimera". In Greek mythology, the chimera was a fire-breathing monster with the body parts of multiple animals.
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