ALLOXAN DIABETES Meaning and
Definition
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Alloxan Diabetes, also known as chemically induced diabetes or alloxan-induced diabetes, is a laboratory-induced model of diabetes in animals. It is a condition characterized by elevated blood glucose levels resulting from the destruction of insulin-producing cells in the pancreas. Alloxan, a toxic compound derived from the oxidation of uric acid, is commonly used to induce diabetes in experimental animals such as rats and mice.
The mechanism of alloxan-induced diabetes involves the selective destruction of beta cells in the islets of Langerhans, which are responsible for the secretion of insulin. Alloxan exerts its toxic effect by generating reactive oxygen species that cause DNA damage and cellular death specifically in these insulin-producing cells. As a result, the animals develop hyperglycemia and the inability to regulate blood glucose levels, mimicking many aspects of human diabetes.
Alloxan Diabetes is widely utilized as an experimental model to study the pathogenesis, prevention, and treatment strategies for diabetes. It allows researchers to investigate various aspects of the disease, such as the role of oxidative stress, beta cell dysfunction, hyperglycemia, and complications associated with diabetes. Alloxan-induced diabetes models are frequently used to evaluate the efficacy of potential antidiabetic drugs, understand the underlying mechanisms of disease progression, and develop new therapeutic interventions for diabetes management.
In summary, Alloxan Diabetes refers to the laboratory-induced diabetic state in animals resulting from the destruction of insulin-producing beta cells using the chemical compound alloxan.
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Etymology of ALLOXAN DIABETES
The word "alloxan diabetes" is a medical term that refers to a type of diabetes caused by the toxic compound called alloxan. Here is the etymology of each component:
1. Alloxan: The term "alloxan" originates from the chemical name "allantoxanic acid". first isolated and identified in the early 19th century by the Austrian chemist Jobst Heinrich Vom Stein. The term "allantoxanic" is derived from "allantois", the membrane surrounding the embryo of certain reptiles, birds, and mammals, and "oxan", which refers to its chemical structure. The "ox" suffix usually indicates the presence of oxygen.
2. Diabetes: The term "diabetes" has its roots in ancient Greek. It is derived from the Greek word "diabētēs", meaning "passing through" or "siphon".
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