AGGRECAN Meaning and
Definition
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Aggrecan is a type of large proteoglycan found in the extracellular matrix of cartilage, the flexible connective tissue that provides cushioning and support to the joints. It is one of the major components of cartilage and plays a critical role in maintaining its structural integrity.
Aggrecan is composed of a protein core to which various sugar molecules called glycosaminoglycans (GAGs) are attached. These GAG chains are responsible for the water-retaining properties of aggrecan, allowing it to absorb and hold onto large amounts of water. This ensures the cartilage remains hydrated and maintains its shock-absorbing function.
The high content of negatively charged GAGs in aggrecan also enables it to interact with other molecules in the extracellular matrix, such as collagen, forming a complex and dynamic network that provides strength and flexibility to the cartilage.
In addition to its structural role, aggrecan also influences the behavior of cells within the cartilage. It interacts with specific cell surface receptors, affecting the signaling pathways that regulate cell proliferation, differentiation, and synthesis of other extracellular matrix components.
Given its importance in maintaining the health and function of cartilage, any abnormalities or alterations in the aggrecan molecule can lead to various cartilage-related disorders, such as osteoarthritis, where the cartilage gradually breaks down leading to joint pain and stiffness.
Common Misspellings for AGGRECAN
- AGGREkAN
- AGGREgAN
- AGGREaAN
- AGGREbAN
- AGGRECiN
- AGGRECeN
- AGGRECcN
- AGGRECAf
- AGGRECAl
- AGGRECAo
- a ggrecan
- ag grecan
- agg recan
- aggr ecan
- aggre can
- aggrec an
- aggreca n
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