How Do You Spell AGAMMAGLOBULINEMIAS?

Pronunciation: [ˌaɡɐmˌaɡləbjˌʊla͡ɪnˈiːmi͡əz] (IPA)

Agammaglobulinemias is a rare genetic disorder that affects the immune system. The spelling of this word can be broken down into its individual sounds using the International Phonetic Alphabet (IPA). The first sound is "a" as in "apple," followed by "g" as in "goat," and "am" as in "ham." The next sound is a short "a" as in "cat," followed by "glob" as in "global," and "ulin" as in "underling." The final syllables are "emias," pronounced as "ee-mee-us." Together, these sounds create the full spelling of agammaglobulinemias.

AGAMMAGLOBULINEMIAS Meaning and Definition

1. Agammaglobulinemias, also known as agammaglobulinemia or hypogammaglobulinemia (the latter term being more commonly used), is a group of rare genetic disorders that cause the absence or significantly low levels of specific antibodies in the blood. The word itself is a combination of different components: "a" meaning without, "gamma" referring to the gamma globulin fraction of blood proteins, and "emia," indicating a condition of the blood.

   In individuals affected by agammaglobulinemias, the immune system is unable to produce enough immunoglobulins, particularly immunoglobulinG (IgG), immunoglobulinM (IgM), and immunoglobulinA (IgA). These immunoglobulins are critical components of the body's defense mechanism against various infections caused by bacteria, viruses, and other pathogens.

   As a result, individuals with agammaglobulinemias have weakened immune systems and are highly susceptible to recurrent and severe bacterial infections, such as pneumonia, sinusitis, and ear infections. The symptoms usually manifest early in life, often during infancy or early childhood.

   Treatment options for agammaglobulinemias typically involve regular infusions of immunoglobulin replacement therapy (IVIG) to increase the antibody levels in the blood and prevent infections. Antibiotics may also be prescribed to manage and treat specific infections.

   Agammaglobulinemias are typically inherited in an X-linked recessive manner, meaning the affected gene is located on the X chromosome. Consequently, males are more frequently affected while females may be carriers of the gene. Genetic counseling is crucial for affected individuals and their families to better understand the condition and the associated risks.

Common Misspellings for AGAMMAGLOBULINEMIAS

• zgammaglobulinemias
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• agajmaglobulinemias
• agamnaglobulinemias
• agamkaglobulinemias
• agamjaglobulinemias

Etymology of AGAMMAGLOBULINEMIAS

The word "agammaglobulinemias" is derived from Greek and Latin roots.

1. "A-" is a prefix in Greek, meaning "without" or "not".

2. "Gamme" comes from the Greek word "gamma", which refers to the third letter of the Greek alphabet. In medical terminology, it is used to relate to immunoglobulins or antibodies.

3. "Globulin" is derived from the Latin "globus", meaning "a round body" or "a sphere". In medical terms, it refers to a group of proteins found in the blood plasma, including immunoglobulins.

4. Finally, "-emia" is a suffix of Greek origin that denotes "a condition of the blood" or "a presence of a substance in the blood".