Acrania is a medical term that refers to the absence of a cranium, or skull. The pronunciation of acrania is [əˈkreɪniə], with the "a" sound at the beginning being pronounced as "uh," followed by a stressed "krai" sound and finishing with a "niə" sound which represents the "nia" at the end of the word. The phonetic transcription of acrania shows that it is pronounced with a long "a" sound and the stress on the second syllable. Anyone using this term should be familiar with its correct IPA pronunciation.
Acrania is a medical term that refers to a congenital birth defect characterized by the absence of a major part or the entire calvaria (skull). It is a rare and severe anomaly in which the fetus or newborn is born without the top, front, or back portion of the skull, leading to the exposure of the underlying brain tissue.
Individuals affected by acrania generally exhibit a malformed or underdeveloped brain, along with other possible associated abnormalities such as facial malformations, neural tube defects, and abnormalities in the development of the eyes. The condition is typically diagnosed during prenatal ultrasound examinations, as it is highly visible due to the absence of skull bones.
Acrania is thought to occur due to a failure in the formation of the cranial vault during early embryonic development. It is often associated with a condition known as anencephaly, which is characterized by the absence of a significant portion of the brain, skull, and scalp.
Unfortunately, acrania is incompatible with life, as the severe brain malformation and exposure to external factors increase the risk of infection and damage to the exposed neural tissue. As a result, affected individuals usually die prenatally or shortly after birth. There is no known cure for acrania, and the primary approach is prevention through genetic counseling and early detection during routine prenatal screening.
Congenital absence of most or all of the bones of the cranium.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "Acrania" is derived from the Greek roots "a-" meaning "without" or "lacking", and "kranion" meaning "skull". It refers to a medical condition characterized by the absence of a skull. "Acrania" is predominantly used in the field of developmental biology and anatomy to describe a rare congenital anomaly where the skull fails to form properly during embryonic development.