How Do You Spell ABDERHALDEN REACTION OR TEST?

Pronunciation: [ˈabdəhˌaldən ɹɪˈakʃən ɔː tˈɛst] (IPA)

The Abderhalden reaction or test is a diagnostic tool used to detect the presence of certain amino acids in the blood. This reaction was named after Emil Abderhalden, a Swiss biochemist who developed the test. The word "Abderhalden" is pronounced [æbdɛrˈhɑːldən] in IPA phonetic transcription. The spelling of the word reflects the Germanic origin of Abderhalden's name, with the use of a "d" instead of a "t" in the middle of the word. The Abderhalden reaction is now considered outdated and has been replaced by newer diagnostic tools.

ABDERHALDEN REACTION OR TEST Meaning and Definition

1. The Abderhalden reaction, also known as the Abderhalden test, is a biochemical test used to detect the presence of specific antibodies in the blood or other bodily fluids. It was developed by Swiss biochemist Emil Abderhalden in the early 20th century as a means of diagnosing various diseases and identifying specific antigens.

   The test is based on the principle of antigen-antibody interactions. When the body is exposed to foreign substances such as bacteria, viruses, or other pathogens, it produces specific proteins called antibodies to help fight against these invaders. The Abderhalden reaction utilizes these antibodies to detect and identify the specific antigens they are directed against.

   To perform the Abderhalden test, a sample of the patient's blood or other bodily fluid is taken and mixed with a specific antigen. If the patient has previously been exposed to that antigen, their body would have produced specific antibodies against it. If these antibodies are present in the sample, they will bind to the antigen, forming an immune complex. This complex is then observed using various methods such as color changes, precipitate formation, or other indicators to confirm the presence of the antibodies.

   The Abderhalden reaction has been utilized in the diagnosis of various diseases, such as autoimmune disorders, certain types of cancer, and some infectious diseases. However, due to technical limitations and the development of more advanced diagnostic methods, the use of the Abderhalden test has declined in recent years.

2. To determine the presence of protective ferments in the blood; one-half gram of the prepared albumin (from the placenta, cancer, urine, or what not) is placed in a diffusion shell, together with 1.5 c.c. of the serum to be tested, and the shell is suspended in a test-tube containing 20 c.c. sterile distilled water; the tube containing the shell is then incubated at 37°C. for 16 hours, after which 10 c.c. of the dialysate is removed and boiled for one minute with 0.2 c.c. ninhydrin; the development of a violet color within half an hour indicates a positive reaction. The test has been used to detect pregnancy, malignant disease, exophthalmic goiter, dementia precox, and various other conditions. The above is called the dialysis test; a less commonly employed form is called the optical test: the prepared albumin and the serum to be tested are mixed and after a definite period the fluid is examined by a polariscope to determine whether the presence of transformation products has effected any rotation differences.

   A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

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